Abstract

Blending a mixture of powders to a homogeneous system is a crucial step in many manufacturing processes.
To achieve a high quality of the end product, powder mixtures should be made with high content
uniformity. For instance, producing uniform tablets depends on the homogeneous dispersion of active
pharmaceutical ingredient (API), often in low level quantities, into excipients. To control the uniformity
of a powder mixture, the first required step is to estimate the powder content information during blending.
There are several powder homogeneity evaluation techniques which differ in accuracy, fundamental
basis, cost and operating conditions. In this article, emerging techniques for the analysis of powder content
and powder blend uniformity, are explained and compared. The advantages and drawbacks of all the
techniques are reviewed to help the readers to select the appropriate equipment for the powder mixing
evaluation. In addition, the paper highlights the recent innovative on-line measurement techniques used
for the non-invasive evaluation of the mixing performance.