Klonizakis, Markos, Tew, G. A., Michaels, J. A. and Saxton, J. M. (2010) Effects of upper-limb exercise on lower-limb cutaneous microvascular function in post-surgical varicose-vein patients. European Journal of Applied Physiolology, 109 (6). pp. 1221-1224. ISSN 1439-6319
Full content URL: http://dx.doi.org/10.1007/s00421-010-1471-1
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
Regular walking exercise attenuates lower-limb
cutaneous microvascular endothelial dysfunction in postsurgical
varicose-vein patients. This study assessed the
effects of upper-limb exercise training on lower-limb cutaneous
microvascular function in this patient group. Six
post-surgical (4–5 weeks) varicose-vein patients completed
an 8-week arm-crank exercise training programme.
Changes in cutaneous microvascular function of the lower
leg were assessed using laser Doppler Xowmetry
and iontophoretic administration of endothelial-dependent
and -independent agonists [acetylcholine (ACh) and sodium
nitroprusside (SNP), respectively]. At 8 weeks, median
lower-limb cutaneous vasodilator responsives to ACh and
SNP remained unchanged relative to baseline (e.g. 6 mC:
37 (interquartile range 24–63) vs. 40 (20–71) PU and 35
(23–48) vs. 38 (21–64) PU, respectively for the supine
position). Upper-limb exercise appears ineffective for
improving lower-limb cutaneous microvascular function in
post-surgical varicose-vein patients. Therefore, limb speci-
ficity appears an important factor in optimal exercise
prescription for these patients.
| Additional Information: | Regular walking exercise attenuates lower-limb cutaneous microvascular endothelial dysfunction in postsurgical varicose-vein patients. This study assessed the effects of upper-limb exercise training on lower-limb cutaneous microvascular function in this patient group. Six post-surgical (4–5 weeks) varicose-vein patients completed an 8-week arm-crank exercise training programme. Changes in cutaneous microvascular function of the lower leg were assessed using laser Doppler Xowmetry and iontophoretic administration of endothelial-dependent and -independent agonists [acetylcholine (ACh) and sodium nitroprusside (SNP), respectively]. At 8 weeks, median lower-limb cutaneous vasodilator responsives to ACh and SNP remained unchanged relative to baseline (e.g. 6 mC: 37 (interquartile range 24–63) vs. 40 (20–71) PU and 35 (23–48) vs. 38 (21–64) PU, respectively for the supine position). Upper-limb exercise appears ineffective for improving lower-limb cutaneous microvascular function in post-surgical varicose-vein patients. Therefore, limb speci- ficity appears an important factor in optimal exercise prescription for these patients. |
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| Keywords: | Skin blood flow, Upper-limb exercise, Venous disease, Laser Doppler flowmetry |
| Subjects: | A Medicine and Dentistry > A300 Clinical Medicine |
| Divisions: | College of Social Science > School of Health & Social Care |
| ID Code: | 3540 |
| Deposited On: | 28 Oct 2010 14:22 |
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