Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging

Horcajada, Patricia, Chalati, Tamim, Serre, Christian , Gillet, Brigitte, Sebrie, Catherine, Baati, Tarek, Eubank, Jarrod, Heurtaux, Daniela, Clayette, Pascal, Kreuz, Christine, Chang, Jong-San, Hwang, Young Kyu, Marsaud, Veronique, Bories, Phuong-Nhi, Cynober, Luc, Gil, Sophie, Ferey, Gerard, Couvreur, Patrick and Gref, Ruxandra (2010) Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. Nature Materials, 9 . pp. 172-178. ISSN 1476-4660

Full content URL: https://www.nature.com/articles/nmat2608

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In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading (usually less than 5 wt% of the transported drug versus the carrier material) and/or rapid release of the proportion of the drug that is simply adsorbed (or anchored) at the external surface of the nanocarrier. In this context, porous hybrid solids, with the ability to tune their structures and porosities for better drug interactions and high loadings, are well suited to serve as nanocarriers for delivery and imaging applications. Here we show that specific non-toxic porous iron(III)-based metal–organic frameworks with engineered cores and surfaces, aswell as imaging properties, function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs (that is, busulfan, azidothymidine triphosphate, doxorubicin or cidofovir) against cancer and AIDS. In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments.

Additional Information:The final published version of this article is available online at: https://www.nature.com/articles/nmat2608
Keywords:Nanoparticles, Drug Delivery, MOF
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
Divisions:College of Science > School of Pharmacy
ID Code:32569
Deposited On:13 Aug 2018 10:04

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