Munshi, Tasnim, Scowen, Ian, Seaton, Colin C. et al, Thomas, Rayan R., Essifaow, Eman A. A. and Nauha, Elisa
Structural motifs in salts of sulfathiazole: implications for design of salt forms in pharmaceuticals APIs†.
CrystEngComm
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ISSN 1466-803
Full content URL: http://pubs.rsc.org/en/content/articlelanding/2018...
Structural motifs in salts of sulfathiazole: implications for design of salt forms in pharmaceuticals APIs† | | ![[img]](http://eprints.lincoln.ac.uk/32254/1.hassmallThumbnailVersion/C8CE00606G.pdf) [Download] |
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Item Type: | Article |
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Item Status: | Live Archive |
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Abstract
The creation of salts is a frequently used approach for the modification of physicochemical properties of
an active pharmaceutical ingredient. Despite the frequency of application, there has been little research
into the structural–property relationships of the final material and the nature of the counterion present. This
work reports on five new salts of sulfathiazole and compares the energetics of the intermolecular interactions
with variation in the crystal packing motifs.
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