Evaluation of larvicidal activity of esters of 4-mercapto-2-butenoic acid against Aedes albopictus (Diptera: Culicidae)

Pezzi, Marco, Zamberlan, Francesco, Chicca, Milvia and Leis, Marilena (2018) Evaluation of larvicidal activity of esters of 4-mercapto-2-butenoic acid against Aedes albopictus (Diptera: Culicidae). Saudi Journal of Biological Sciences . ISSN 1319-562X

Full content URL: https://doi.org/10.1016/j.sjbs.2018.03.011

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Abstract Aedes albopictus (Skuse) (Diptera: Culicidae), an aggressive and annoying vector of several arbovirus including Chikungunya and Zika, is a serious health problem worldwide. Control of this mosquito is difficult because of high adaptability, egg resistance to dehydration and ability to exploit many man-made microhabitats. The most effective strategy appears the control of larval population. Based on previous data showing a larvicidal effect of plant extracts containing sulfhydryl and isothiocyanate compounds, we evaluated by bioassays the toxicity of three synthetic esters of 4-mercapto-2-butenoic acid on larvae of A. albopictus in comparison to cypermethrin. Among the compounds tested, the most effective was n-octyl 4-mercapto-2-butenoate, about 5 times more effective than ethyl 4-mercaptobut-2-enoate and about 20 times more effective than menthyl 4-mercaptobut-2-enoate. We advance the hypothesis that the larvicidal properties of n-octyl 4-mercapto-2-butenoate are due to its hydrophobic alkyl chain, longer than that of the other two compounds. This chain confers to the molecule the ability to spread on water surface and interfere with larval respiration. The larvicidal activity of n-octyl 4-mercapto-2-butenoate against A. albopictus appears interesting and may be developed after toxicological evaluation on vertebrates and humans, and environmental toxicity tests in compliance with {WHO} and {ECDC} rules.

Keywords:Wittig synthesis, mosquito, larvicidal, bioassay, sulphur, alkyl chain
Subjects:C Biological Sciences > C710 Applied Molecular Biology, Biophysics and Biochemistry
F Physical Sciences > F110 Applied Chemistry
F Physical Sciences > F100 Chemistry
F Physical Sciences > F165 Biomolecular Chemistry
C Biological Sciences > C720 Biological Chemistry
F Physical Sciences > F160 Organic Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:31407
Deposited On:22 Mar 2018 16:21

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