Abstract

The understanding of gene regulation plays an important role in epigenetics, which describe the molecular mechanisms by which environmental factors control the switching on and off of gene activities (Biel, M., et al. Angew. Chem. Int. Ed. 2005, 44, 3186–3216). One of the major mechanisms of epigenetic control is methylation and demethylation of lysine residues in histone proteins. The desire to understand the function of these modifications, promoted the development of artificial molecules that recognize and bind methyllysine (Minaker, S.A., et al. J. Am. Chem. Soc. 2012, 134, 11674–11680). They are promising for a number of applications, e.g., as reagents in biochemical assays, in cell biology and to inhibit protein-protein interactions (Beshara, C.S., et al. ChemBioChem 2010, 11, 63–66). Thereby, the discrimination of differently methylated lysines (monomethyl, dimethyl, trimethyl), both as a modified amino acid and in proteins, is of special interest.

The 25th Conference of GP2A was held on 31 August and 1 September 2017 in Liverpool, UK, with the aim of exchange of ideas and experience, particularly amongst young medicinal chemists.
Topics included bioactive compounds from plants and lichens, and design and development of drugs.
Abstracts of invited lectures, proffered oral presentations, flash presentations and posters presented during the meeting are collected in this report.