Supramolecular receptors for the recognition and discrimination of post-translationally methylated lysines (PT2)

Gruber, Tobias (2017) Supramolecular receptors for the recognition and discrimination of post-translationally methylated lysines (PT2). In: 25th GP2A Medicinal Chemistry Conference, 31 Aug - 1 Sep 2017, Liverpool John Moores University.

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Item Type:Conference or Workshop contribution (Presentation)
Item Status:Live Archive


The understanding of gene regulation plays an important role in epigenetics, which describe the molecular mechanisms by which environmental factors control the switching on and off of gene activities (Biel, M., et al. Angew. Chem. Int. Ed. 2005, 44, 3186–3216). One of the major mechanisms of epigenetic control is methylation and demethylation of lysine residues in histone proteins. The desire to understand the function of these modifications, promoted the development of artificial molecules that recognize and bind methyllysine (Minaker, S.A., et al. J. Am. Chem. Soc. 2012, 134, 11674–11680). They are promising for a number of applications, e.g., as reagents in biochemical assays, in cell biology and to inhibit protein-protein interactions (Beshara, C.S., et al. ChemBioChem 2010, 11, 63–66). Thereby, the discrimination of differently methylated lysines (monomethyl, dimethyl, trimethyl), both as a modified amino acid and in proteins, is of special interest.

The 25th Conference of GP2A was held on 31 August and 1 September 2017 in Liverpool, UK, with the aim of exchange of ideas and experience, particularly amongst young medicinal chemists.
Topics included bioactive compounds from plants and lichens, and design and development of drugs.
Abstracts of invited lectures, proffered oral presentations, flash presentations and posters presented during the meeting are collected in this report.

Additional Information:Pharmaceuticals 2017, 10(4), 97
Keywords:medicinal chemistry, drug design, Natural product, structure-based, prodrug
Subjects:F Physical Sciences > F150 Medicinal Chemistry
F Physical Sciences > F151 Pharmaceutical Chemistry
Divisions:College of Science > School of Pharmacy
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ID Code:30105
Deposited On:15 Mar 2018 16:09

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