Liposome-coated iron fumarate metal-organic framework nanoparticles for combination therapy

Illes, Bernhard, Wuttke, Stefan and Engelke, Hanna (2017) Liposome-coated iron fumarate metal-organic framework nanoparticles for combination therapy. Nanomaterials (Basel, Switzerland), 7 (11). ISSN 2079-4991

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One of the main problems for effective treatment of cancer is resistances, which often require combination therapy-for effective treatment. While there are already some potential drug carriers-e.g., liposomes, available for treatment-the effective loading and retention of the desired drug ratio can be challenging. To address this challenge, we propose a new type of drug carrier: liposome-coated metal-organic framework (MOF) nanoparticles. They combine the advantages of liposomes with an easy and efficient loading process. In this work, we present the successful synthesis of liposome-coated MOF nanoparticles via the fusion method. The resulting particles, once loaded, show no premature leakage and an efficient release. Their successful loading with both single and multiple drugs at the same time makes them an interesting candidate for use in combination therapy.

Subjects:F Physical Sciences > F151 Pharmaceutical Chemistry
B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Chemistry
ID Code:29395
Deposited On:28 Nov 2017 12:14

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