A novel antimicrobial urinary catheter

Jayanth, Aiden M., Mitchell, Graham H. and Alsam, Selwa (2015) A novel antimicrobial urinary catheter. In: Congress of the Institute of Biomedical Science, 28 - 30 September 2015, Birmingham.

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Item Type:Conference or Workshop contribution (Presentation)
Item Status:Live Archive


Urinary tract infections (UTI) are one of the most common healthcare associated infections (HCAI) accounting for 17.2% of the total HCAI’s in England, out of which 43% of infections were associated with the use of an indwelling catheter. Catheter associated UTI (CAUTI) caused by uropathogenic biofilm formation is responsible for prolonged hospital admissions, increased costs and significant morbidity. The NHS routinely uses silver alloy-coated latex catheters and silicone catheters impregnated with nitrofurazone to prevent CAUTIs. However, numerous studies have questioned their antimicrobial efficacy. This raises the urgent need to develop novel catheters that can inhibit bacterial colonization. The present study provides the in vitro evidence to support the use of novel Cetylpyridinium chloride (CPC) impregnated catheters in preventing biofilm formation. CPC impregnated catheters were prepared using a 3-step medical implant impregnation process. A biofilm microtitre plate assay was used to evaluate the antimicrobial effect of CPC, and the efficacy of impregnated catheters was assessed using an in vitro biofilm catheter colonization model. Non-impregnated catheters were used as control. Growth of Proteus mirabilis and extended spectrum beta lactamase (ESBL) positive and negative strains of Escherichia coli and Klebsiella was completely inhibited by CPC (30 μg/ml) after 24h of incubation in artificial urine medium. The novel CPC impregnated catheters were highly efficacious in inhibiting biofilm colonization of all uropathogens tested at all time intervals. Taken together, our preliminary results provide promising evidence for the potential application of CPC impregnated catheters in preventing CAUTIs

Keywords:Biofilms, Urinary Tract Infections, Urinary Catheters
Subjects:C Biological Sciences > C521 Medical Microbiology
Divisions:College of Social Science > School of Health & Social Care
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ID Code:29312
Deposited On:07 Nov 2017 09:29

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