Multidrug-resistant TB in Zambia: review of national data from 2000 to 2011

Kapata, Nathan, Chanda-Kapata, Pascalina, Bates, Matthew , Mwaba, Peter, Cobelens, Frank, Grobusch, Martin P. and Zumla, Alimuddin (2013) Multidrug-resistant TB in Zambia: review of national data from 2000 to 2011. Tropical Medicine and International Health, 18 (11). pp. 1386-1391. ISSN 1360-2276


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BackgroundMultidrug-resistant tuberculosis (MDR-TB) is posing a great threat to global TB control. The burden in Zambia is not well defined because routine surveillance data are scarce. We reviewed national MDR-TB data for the last decade to inform future public health policy with respect to MDR-TB in Zambia. MethodRetrospective review of national surveillance of MDR-TB data, TB programme and laboratory reports between 2000 and 2011. ResultsThe total number of DSTs performed during this 11-year period was 2038 and accounted for 2.6% (2038/78639) of all the retreatment cases notified. The total number of diagnosed MDR-TB cases for this period was 446, of which 56.3% (251/446) were male and 41.7% (186/446) female. Only one child was found to have MDR-TB. Poly-drug resistance accounted for 18.9% (172/911) of the DR-TB cases and 8.4% of the total DSTs. 8.8% (80/911) of the DR-TB cases showed either rifampicin mono- or poly-resistance other than MDR-TB. No XDR-TB was reported. There were no data available on DR-TB and HIV co-infection. Only 65 MDR-TB patients were notified and put on second-line treatment according to WHO guidelines. ConclusionsMultidrug-resistant tuberculosis may be an emerging challenge in Zambia. There is a need to invest in improving the capacity of the TB programme to detect and manage MDR-TB.

Keywords:tuberculosi, multidrug-resistant tuberculosis, surveillance, retreatments, diagnosis, Zambia}
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Science > School of Life Sciences
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ID Code:28381
Deposited On:26 Nov 2017 12:07

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