Taking forward the World TB Day 2016 theme `Unite to End Tuberculosis' for the WHO Africa Region

Ntoumi, Francine, Kaleebu, Pontiano, Macete, Eusebio , Mfinanga, Sayoki, Chakaya, Jeremiah, Yeboah-Manu, Dorothy, Bates, Matthew, Mwaba, Peter, Maeurer, Markus, Petersen, Eskild and Zumla, Alimuddin (2016) Taking forward the World TB Day 2016 theme `Unite to End Tuberculosis' for the WHO Africa Region. International Journal of Infectious Diseases, 46 . pp. 34-37. ISSN 1201-9712

Full content URL: https://doi.org/10.1016/j.ijid.2016.03.003

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Tuberculosis (TB) remains a global emergency, with an estimated 9.6 million new TB cases worldwide reported in 2014. Twenty-eight percent of these cases were in the World Health Organization (WHO) Africa Region, where the annual case detection rate was 281 per 100 000 population-more than double the global average of 133 per 100 000. Of the 9.6 million people who developed TB, an estimated 1.2 million (12%) were HIV-positive, and the Africa Region accounted for 74% of these cases. Three million people with TB remain undiagnosed and untreated. Globally, an estimated 480 000 had multidrug-resistant TB (MDR-TB). Whilst of the African countries, only South Africa has reported a high prevalence of MDR-TB, it is likely that all of Sub-Saharan Africa has an unreported high load of drug-resistant TB. Tragically, in 2014, only 48% of individuals diagnosed with MDR-TB had successful treatment and an estimated 190 000 people died of MDR-TB. Of the global TB funding gap of US$ 0.8 billion, the largest funding gap was in the Africa Region, amounting to US$ 0.4 billion in 2015. The MDR-TB pandemic in particular now threatens to devastate entire regions and may fundamentally alter the life-expectancy and demographic profile of many countries in Sub-Saharan Africa. The theme designated for this year's World TB Day, March 24, 2016, is `Unite to End TB'. From the Africa Region, there is an urgent need to seriously address the political, economic, and social factors that influence host-Mycobacterium tuberculosis interactions and result in disease. Recent political and funder initiatives that provide renewed hope for the alleviation of Africa's TB and TB/ HIV problems are discussed. (C) 2016 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keywords:World TB Da, Tuberculosis, Treatment, Multidrug-resistant TB, EDCTP, Advocacy, Unite}
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Science > School of Life Sciences
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ID Code:28353
Deposited On:08 Sep 2017 15:37

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