Abstract

Proliposomes were manufactured by coating sucrose carrier particles with a lipid phase comprising the phospholipid Phospholipon® 90H and the anticancer drug Paclitaxel. Hydration of the proliposomes with deionized water followed by probe-sonication generated nano-sized liposomes (160.50 nm) with slightly negative zeta potential (-0.79 mV). The entrapment efficiency of Paclitaxel was as high as 88.54 (1.93 mgs drug per 100 mg lipid). The solubility of Paclitaxel in our study was 965.16 μg/ml, which is almost 10,000 times higher than the literature reported solubility of this drug. Overall, using the proliposome manufacturing approach we have developed a Paclitaxel liposome formulation with highly desirable characteristics for further in vitro and in vivo investigations. © Nova Science Publishers, Inc.