Characteristic of silicon doped diamond like carbon thin films on surface properties and human serum albumin adsorption

Ahmed, M. H., Byrne, J. A. and Ahmed, W. (2015) Characteristic of silicon doped diamond like carbon thin films on surface properties and human serum albumin adsorption. Diamond and Related Materials, 55 . pp. 108-116. ISSN 0925-9635

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Abstract Diamond-like carbon (DLC) coatings are useful for creating biocompatible surfaces for medical implants. DLC and silicon doped DLC have been synthesised using plasma enhanced chemical vapour deposition (PECVD). The effects of surface morphology on the interaction of human serum albumin (HSA) with doped and undoped DLC films have been investigated using a range of surface analysis techniques using Raman spectroscopy and atomic force microscopy (AFM). Raman spectra of doped DLC show that silicon doped DLC reduces the growth range of the ID/IG ratio, with a significant red-shift of the G peak position. Following exposure to protein, for undoped DLC the peaks at 1664 cm- 1 and around 1241 cm- 1 can be attributed to amide I and III, respectively, with an increase in the surface morphology of the surfaces giving some indication of the protein structure on the surfaces. Results indicate that HSA exhibit the majority of β-sheet during the adsorption on the surfaces. The results showed that the silicon incorporation DLC tends to increase of surface roughness and the adsorbed level of HSA is higher with higher levels of silicon doping of the DLC. Therefore, doping DLC may provide a method of controlling the adsorption of protein. © 2015 Elsevier B.V. All rights reserved.

Keywords:Adsorption, Amorphous carbon, Atomic force microscopy, Biocompatibility, Body fluids, Carbon, Carbon films, Diamonds, Morphology, Plasma enhanced chemical vapor deposition, Proteins, Raman spectroscopy, Semiconductor doping, Silicon, Surface analysis, Surface morphology, Surface roughness, Adsorption of proteins, Biocompatible surfaces, Diamond like carbon, Diamond-like carbon coatings, Doped diamond-like carbon, Human serum albumins, Plasma enhanced chemical vapour depositions (PECVD), Surface analysis techniques, Diamond like carbon films, NotOAChecked
Divisions:College of Science > School of Mathematics and Physics
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ID Code:27121
Deposited On:05 Jul 2017 11:42

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