PEGylated graphene oxide for tumor-targeted delivery of paclitaxel

Xu, H., Fan, M., Elhissi, A. M. A. , Zhang, Z., Wan, K.-W., Ahmed, W., Phoenix, D. A. and Sun, X. (2015) PEGylated graphene oxide for tumor-targeted delivery of paclitaxel. Nanomedicine, 10 (8). pp. 1247-1262. ISSN 1743-5889

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Aim: The graphene oxide (GO) sheet has been considered one of the most promising carbon derivatives in the field of material science for the past few years and has shown excellent tumor-targeting ability, biocompatibility and low toxicity. We have endeavored to conjugate paclitaxel (PTX) to GO molecule and investigate its anticancer efficacy. Materials & Methods: We conjugated the anticancer drug PTX to aminated PEG chains on GO sheets through covalent bonds to get GO-PEG-PTX complexes. The tissue distribution and anticancer efficacy of GO-PEG-PTX were then investigated using a B16 melanoma cancer-bearing C57 mice model. Results: The GO-PEG-PTX complexes exhibited excellent water solubility and biocompatibility. Compared with the traditional formulation of PTX (Taxol®), GO-PEG-PTX has shown prolonged blood circulation time as well as high tumor-targeting and -suppressing efficacy. Conclusion: PEGylated graphene oxide is an excellent nanocarrier for paclitaxel for cancer targeting. © 2015 Future Medicine Ltd.

Keywords:graphene oxide, macrogol, nanocarrier, paclitaxel, antineoplastic agent, drug carrier, graphite, macrogol derivative, oxide, paclitaxel, animal cell, animal experiment, animal model, animal tissue, antineoplastic activity, Article, biocompatibility, complex formation, covalent bond, drug conjugation, drug delivery system, drug efficacy, drug formulation, drug solubility, female, human, human cell, melanoma, melanoma B16, mouse, nonhuman, priority journal, rat, tissue distribution, animal, C57BL mouse, chemistry, pathology, tumor cell line, Wistar rat, Animals, Antineoplastic Agents, Phytogenic, Cell Line, Tumor, Drug Carriers, Drug Delivery Systems, Mice, Mice, Inbred C57BL, Oxides, Polyethylene Glycols, Rats, Wistar, NotOAChecked
Divisions:College of Science > School of Mathematics and Physics
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ID Code:27119
Deposited On:05 Jul 2017 11:43

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