25I-NBOH: a new potent serotonin 5-HT2A receptor agonist identified in blotter paper seizures in Brazil

Arantes, Luciano Chaves, Júnior, Ettore Ferrari, de Souza, Luciano Figueiredo , Cardoso, Andriele Costa, Alcântara, Thaynara Lino Fernandes, Lião, Luciano Morais, Machado, Yuri, Lordeiro, Rogério Araújo, Neto, José Coelho and Andrade, Ana Flávia B. (2017) 25I-NBOH: a new potent serotonin 5-HT2A receptor agonist identified in blotter paper seizures in Brazil. Forensic Toxicology . ISSN 1860-8965

Full content URL: http://dx.doi.org/10.1007/s11419-017-0357-x

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Abstract

A new potent serotonin 5-HT2A receptor agonist was identified in blotter papers by several state level forensic laboratories in Brazil. 25I-NBOH is a labile molecule, which fragments into 2C-I when analyzed by routine seized material screening gas chromatography (GC) methods. GC – mass spectrometry (MS), liquid chromatography – quadrupole time-of-flight – MS, Fourier transform infrared and nuclear magnetic resonance analyses were performed to complete molecular characterization. Individual doses range from 300 - 1000 g. Despite its being a potent 5-HT2A receptor agonist, 25I-NBOH is neither registered in United Nations Office on Drugs and Crime (UNODC) nor classified as a scheduled substance in most countries. Sweden and Brazil seem to be the only countries to control 25I-NBOH. To our knowledge, this is the first scientific report dealing with identification of 25I-NBOH in actual seizures.

Keywords:25I-NBOH, phenethylamine, NPS, 5-HT2A receptor agonist
Subjects:B Subjects allied to Medicine > B220 Toxicology
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
ID Code:27087
Deposited On:26 Apr 2017 15:32

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