Eves, P. C., MacNeil, S. and Haycock, J. W. (2006) α-Melanocyte stimulating hormone, inflammation and human melanoma. Peptides, 27 (2). pp. 444-452. ISSN 0196-9781
Documents | Others |
|
![]() |
HTML
S0196978105004584 67kB | |
![]() |
PDF
26988 1-s2.0-S0196978105004584-main.pdf - Whole Document Restricted to Repository staff only 293kB |
Item Type: | Article |
---|---|
Item Status: | Live Archive |
Abstract
Alpha-melanocyte stimulating hormone (α-MSH) arises from the proteolytic cleavage of proopiomelanocortin (POMC) and is the most potent naturally occurring melanotropic peptide. The biological effects of α-MSH are mediated via melanocortin receptors (MCRs), which are expressed in virtually every cutaneous cell type. α-MSH has pleiotrophic functions including the modulation of a wide range of inflammatory stimuli such as proinflammatory cytokines, adhesion molecules and inflammatory transcription factors. All of the former would be consistent with a cytoprotective role for this hormone in protecting skin cells from exogenous stress, as would occur following UV exposure or exposure to agents inducing inflammation or oxidative stress. In addition to actions on normal skin cells it also modulates both cutaneous and uveal melanoma cell behavior. With respect to melanoma, α-MSH is intriguing as studies have shown that while α-MSH has the potential to retard metastatic spread (by reducing cell migration and invasion) it is also capable of reducing the ability of the immune system to detect tumor cells (by down regulating adhesion molecules that would normally assist in immune cell interaction with melanoma cells). This review considers the evolving biology of α-MSH and discusses its role in man that extend far beyond pigmentation of skin melanocytes, suggesting that the detoxifying role of α-MSH in inducing melanogenesis is only one aspect of the stress-coping role of this hormone. Indeed melanoma cells may owe at least some of their success to the 'protective' role of α-MSH. © 2005 Elsevier Inc. All rights reserved.
Keywords: | ?-MSH; Melanocortin receptors; Pigmentation |
---|---|
Subjects: | C Biological Sciences > C130 Cell Biology H Engineering > H811 Biochemical Engineering |
Divisions: | Professional services |
Related URLs: | |
ID Code: | 26988 |
Deposited On: | 21 Apr 2017 09:04 |
Repository Staff Only: item control page