Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

Hanauer, Thomas, Hopkinson, Richard J, Patel, Kamel , Li, Yu, Correddu, Danilo, Kawamura, Akane, Sarojini, Vijay, Leung, Ivanhoe K. H. and Gruber, Tobias (2017) Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor. Organic & Biomolecular Chemistry, 15 . pp. 1100-1105. ISSN 1477-0520

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Abstract

Chemical tools that recognise post-translational modifications
have promising applications in biochemistry and in therapy. We
report a simple carboxycalixarene that selectively binds molecules
containing di/trimethylammonium moieties in isolation, in cell
lysates and when incorporated in histone peptides. Our findings
reveal the potential of using carboxycalixarene-based receptors to
study epigenetic regulation.

Keywords:Calix[4]arene, calixarene
Subjects:F Physical Sciences > F160 Organic Chemistry
C Biological Sciences > C720 Biological Chemistry
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Pharmacy
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ID Code:25804
Deposited On:19 Jan 2017 21:10

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