Hanauer, Thomas, Hopkinson, Richard J, Patel, Kamel , Li, Yu, Correddu, Danilo, Kawamura, Akane, Sarojini, Vijay, Leung, Ivanhoe K. H. and Gruber, Tobias (2017) Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor. Organic & Biomolecular Chemistry, 15 . pp. 1100-1105. ISSN 1477-0520
| Documents |
| ||||
|
PDF
__network.uni_staff_S3_tgruber_Hanauer_OBC_Calixarene_lysine_OBC_resub_final.pdf - Whole Document 605kB |
| Item Type: | Article |
|---|---|
| Item Status: | Live Archive |
Abstract
Chemical tools that recognise post-translational modifications
have promising applications in biochemistry and in therapy. We
report a simple carboxycalixarene that selectively binds molecules
containing di/trimethylammonium moieties in isolation, in cell
lysates and when incorporated in histone peptides. Our findings
reveal the potential of using carboxycalixarene-based receptors to
study epigenetic regulation.
| Keywords: | Calix[4]arene, calixarene |
|---|---|
| Subjects: | F Physical Sciences > F160 Organic Chemistry C Biological Sciences > C720 Biological Chemistry F Physical Sciences > F100 Chemistry |
| Divisions: | College of Science > School of Pharmacy |
| Related URLs: | |
| ID Code: | 25804 |
| Deposited On: | 19 Jan 2017 21:10 |
Repository Staff Only: item control page