Abstract

Diabetic retinopathy (DR) remains a major cause of blindness in the developed countries. Geometric and Haemodynamic features are still not widely investigated, especially as biomarkers of progression to DR. Most studies rely on disease vs control design, which introduces errors and limitations, given the diversity of the retinal vascular geometry (small and large vessels). Our studies have mainly focused on investigating the vascular changes within the same patients during a four year period that includes the last three years of pre-DR and 1st year of DR (onset).