Dynamic ventilation imaging from four-dimensional computed tomography

Guerrero, Thomas, Sanders, Kevin, Castillo, Edward , Zhang, Yin, Bidaut, Luc, Pan, Tinsu and Komaki, Ritsuko (2006) Dynamic ventilation imaging from four-dimensional computed tomography. Physics in Medicine and Biology, 51 (4). pp. 777-791. ISSN 0031-9155

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Item Type:Article
Item Status:Live Archive


A novel method for dynamic ventilation imaging of the full respiratory cycle from four-dimensional computed tomography (4D CT) acquired without added contrast is presented. Three cases with 4D CT images obtained with respiratory gated acquisition for radiotherapy treatment planning were selected. Each of the 4D CT data sets was acquired during resting tidal breathing. A deformable image registration algorithm mapped each (voxel) corresponding tissue element across the 4D CT data set. From local average CT values, the change in fraction of air per voxel (i.e. local ventilation) was calculated. A 4D ventilation image set was calculated using pairs formed with the maximum expiration image volume, first the exhalation then the inhalation phases representing a complete breath cycle. A preliminary validation using manually determined lung volumes was performed. The calculated total ventilation was compared to the change in contoured lung volumes between the CT pairs (measured volume). A linear regression resulted in a slope of 1.01 and a correlation coefficient of 0.984 for the ventilation images. The spatial distribution of ventilation was found to be case specific and a 30 difference in mass-specific ventilation between the lower and upper lung halves was found. These images may be useful in radiotherapy planning. © 2006 IOP Publishing Ltd.

Keywords:Image reconstruction, Medical imaging, Patient treatment, Radiotherapy, Tissue, Ventilation, Dynamic ventilation imaging, Four-dimensional computed tomography (4D CT), Radiotherapy treatment, Tissue elements, Computerized tomography, algorithm, article, breathing, clinical article, computer assisted tomography, controlled study, correlation coefficient, dosimetry, exhalation, forced expiratory volume, human, imaging system, information processing, inhalation, linear regression analysis, lung ventilation, lung volume, priority journal, respiratory system, tidal volume, Algorithms, Humans, Imaging, Three-Dimensional, Lung, Pulmonary Ventilation, Radiographic Image Enhancement, Radiographic Image Interpretation, Computer-Assisted, Reproducibility of Results, Sensitivity and Specificity, Subtraction Technique, Tidal Volume, Tomography, X-Ray Computed
Subjects:G Mathematical and Computer Sciences > G400 Computer Science
B Subjects allied to Medicine > B822 Radiography, therapeutic
Divisions:College of Science > School of Computer Science
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ID Code:24151
Deposited On:21 Oct 2016 09:59

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