Cooper, J. D., Simmonds, M. J., Walker, N.M. , Burren, O., Brand, O.J., Guo, H., Wallace, C., Stevens, H., Coleman, G, Franklyn, J.A., Todd, J.A. and Gough, S.C.L. (2012) Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics, 21 (23). pp. 5202-5208. ISSN 0964-6906
Full content URL: http://dx.doi.org/10.1093/hmg/dds357
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2012 HMG Immunochip Seven new GD loci.pdf - Whole Document Available under License Creative Commons Attribution. 114kB |
| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 � 10-6; a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases. © The Author 2012. Published by Oxford University Press.
| Keywords: | article, autoimmune disease, controlled study, female, gene frequency, gene locus, genetic association, genetic susceptibility, genotype, Graves disease, Hashimoto disease, human, major clinical study, male, microarray analysis, priority journal, single nucleotide polymorphism, Autoimmune Diseases, Case-Control Studies, Chromosome Banding, Chromosome Mapping, Genetic Loci, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide, Thyroid Diseases |
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| Subjects: | C Biological Sciences > C420 Human Genetics |
| Divisions: | College of Science > School of Life Sciences |
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| ID Code: | 22601 |
| Deposited On: | 11 Mar 2016 15:45 |
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