GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis

Simmonds, Matthew J. (2013) GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nature Reviews Endocrinology, 9 (5). pp. 277-287. ISSN 1759-5029

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The ability of the immune system to protect the body from attack by foreign antigens is essential for human survival. The immune system can, however, start to attack the body's own organs. An autoimmune response against components of the thyroid gland affects 2-5 of the general population. Considerable familial clustering is also observed in autoimmune thyroid disease (AITD). Teasing out the genetic contribution to AITD over the past 40 years has helped unravel how immune disruption leads to disease onset. Breakthroughs in genome-wide association studies (GWAS) in the past decade have facilitated screening of a greater proportion of the genome, leading to the identification of a before unimaginable number of AITD susceptibility loci. This Review will focus on the new susceptibility loci identified by GWAS, what insights these loci provide about the pathogenesis of AITD and how genetic susceptibility loci shared between different autoimmune diseases could help explain disease co-clustering within individuals and families. This Review also discusses where future efforts should be focused to translate this step forward in our understanding of the genetic contribution to AITD into a better understanding of disease presentation and progression, and improved therapeutic options.© 2013 Macmillan Publishers Limited. All rights reserved.

Keywords:virus antigen, autoimmune disease, autoimmune thyroid disease, B lymphocyte, copy number variation, disease course, gene control, gene locus, genetic association, genetic susceptibility, genetic variability, genotype environment interaction, Graves disease, heritability, human, insulin dependent diabetes mellitus, pathogenesis, priority journal, review, rheumatoid arthritis, T lymphocyte, thyroid disease, B-Lymphocytes, Chromosome Mapping, Epistasis, Genetic, Gene Dosage, Gene-Environment Interaction, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Hashimoto Disease, Humans, Polymorphism, Single Nucleotide
Subjects:C Biological Sciences > C420 Human Genetics
Divisions:College of Science > School of Life Sciences
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ID Code:22599
Deposited On:11 Mar 2016 16:10

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