Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells

Bradshaw, T. D., Junor, M., Patane, A. , Clarke, P., Thomas, N. R., Li, M., Mann, S. and Turyanska, L. (2013) Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells. Journal of Materials Chemistry B, 1 (45). pp. 6254-6260. ISSN 2050-7518

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Colorectal carcinoma (CRC) is the 3rd most common cancer worldwide, thus development of novel therapeutic strategies is imperative. Herein potent, selective dose-dependent antitumor activity of horse spleen apoferritin encapsulated PbS quantum dots (AFt-PbS) against two human-derived colorectal carcinoma cell lines is reported (GI<inf>50</inf> � 70 μg mL-1). Following in vitro exposure to AFt-PbS, CRC cells fail to recover proliferative capacity, and undergo apoptosis triggered by the generation of reactive oxygen species (ROS). In stark contrast, the AFt-PbS nanocomposites do not affect the growth and cell cycle of non-tumor human microvessel endothelial HMEC-1 cells (GI<inf>50</inf> > 500 μg mL -1). In vivo, AFt-PbS QDs are well tolerated by mice. Neither adverse health nor behavioral indicators were observed throughout the 15 day study. The photoluminescence of AFt-PbS combined with selective antitumor activity offer potential development of AFt-PbS for simultaneous non-invasive imaging and treatment of malignant tissue. © The Royal Society of Chemistry.

Keywords:Cell culture, Cell death, Semiconducting lead compounds, Semiconductor quantum dots, Anti-tumor activities, Behavioral indicators, Colorectal carcinoma, Malignant tissues, Non-invasive imaging, PbS quantum dots, Reactive oxygen species, Therapeutic strategy, Endothelial cells
Subjects:B Subjects allied to Medicine > B230 Pharmacy
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:22512
Deposited On:27 Mar 2016 14:59

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