Abstract

Chemoselective ligation of biologically significant moieties through azide alkyne Click
Chemistry has recently received much attention1. The reaction is attractive in that it
regioselectively affords stable triazole linked bioconjugated products under mild conditions.
However, from the view point of the synthetic oligonucleotide chemist, a significant
disadvantage is that the non-thermal reaction requires an in situ generated Cu (I) catalyst.
Unwanted Cu (I) mediated chemistry, specifically oxidative degradation etc.