Christie, Michael (2016) Delving into the Type 1 diabetic islet: evidence that B-cell infiltration of islets is linked to local hyperimmunity and accelerated progression to disease. Diabetes, 65 (5). pp. 1146-1148. ISSN 0012-1797
Full content URL: https://doi.org/10.2337/dbi16-0008
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Item Type: | Article |
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Item Status: | Live Archive |
Abstract
The incidence of type 1 diabetes is increasing, particularly in young children. Multicenter studies across Europe have shown a 5.4% annual rise in type 1 diabetes in children under the age of 5 years (1), increasing the burden on health care resources worldwide. Better understanding of the causes of this increase is required for new therapies or lifestyle changes to reverse this trend. The study by Leete et al. (2) in this issue of Diabetes demonstrates striking differences in the cellular composition of islet inflammation causing type 1 diabetes between children diagnosed before the age of 6 years and those developing disease at an older age that may help define mechanisms underlying accelerated progression to diabetes. The distinguishing feature of islet inflammation in very young children is a high proportion of infiltrating B lymphocytes.
Keywords: | Type 1 diabetes, Autoimmunity, Disease in childhood, JCOpen |
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Subjects: | C Biological Sciences > C550 Immunology B Subjects allied to Medicine > B131 Cellular Pathology |
Divisions: | College of Science > School of Life Sciences |
ID Code: | 22402 |
Deposited On: | 29 Feb 2016 18:20 |
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