Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves

Cowley, S. A., Butter, C., Verghese, S. , Curtis, J. and Turk, J. L. (1988) Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves. International Journal of Leprosy and Other Mycobacterial Diseases, 56 (2). pp. 283-290. ISSN 0148-916X

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Item Type:Article
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A possible model for nerve damage in leprosy has been developed in the sciatic nerve of the guinea pig. Intraneural injection of 107 BCG organisms into an unsensitized animal induces an epithelioid cell granuloma in 2 weeks similar to that found in tuberculoid leprosy patients. In contrast, intraneural injection of 109 cobalt-irradiated Mycobacterium leprae organisms induces a macrophage granuloma in 5 weeks, similar to that found in lepromatous leprosy patients. Histological, immunohistochemical, electron microscopical and electrophysiological studies have demonstrated that the lesions induced in the experimental animals show many of the features documented in studies of nerve damage in leprosy patients.

Keywords:animal cell, animal experiment, animal model, etiology, experimental infection, granuloma, guinea pig, histology, leprosy, mycobacterium leprae, nerve injury, nonhuman, pathogenicity, priority journal, ultrastructure, Animal, Disease Models, Animal, Electrophysiology, Female, Guinea Pigs, Immunohistochemistry, Microscopy, Electron, Mycobacterium bovis, Peripheral Nervous System Diseases, Sciatic Nerve, Support, Non-U.S. Gov't
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
Divisions:College of Science > School of Life Sciences
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ID Code:19876
Deposited On:07 Jan 2016 10:28

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