Abstract

Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomyelitis (CREAE). It was found that class II MHC antigens, fibronin and fibronectin were present in normal blood vessels and at high levels in lesions from animal at all stages of the disease. The possible immunological roles of these antigens suggest their participation in the initiation and maintenace of disease state. © 1989.