Early replication in pulmonary B cells after infection with marek's disease herpesvirus by the respiratory route

Baaten, B. J. G., Staines, K. A., Smith, L. P. , Skinner, H., Davison, T. F. and Butter, C. (2009) Early replication in pulmonary B cells after infection with marek's disease herpesvirus by the respiratory route. Viral Immunology, 22 (6). pp. 431-444. ISSN 0882-8245

19859 Baaten 2009 final.pdf
19859 Baaten 2009 final.pdf - Whole Document

Item Type:Article
Item Status:Live Archive


Natural infection with Marek's disease virus occurs through the respiratory mucosa after chickens inhale dander shed from infected chickens. The early events in the lung following exposure to the feather and squamous epithelial cell debris containing the viral particles remain unclear. In order to elucidate the virological and immunological consequences of MDV infection for the respiratory tract, chickens were infected by intratracheal administration of infective dander. Differences between susceptible and resistant chickens were immediately apparent, with delayed viral replication and earlier onset of interferon (IFN)-γ production in the latter. CD4+ and CD8 + T cells surrounded infected cells in the lung. Although viral replication was evident in macrophages, pulmonary B cells were the main target cell type in susceptible chickens following intratracheal infection with MDV. In accordance, depletion of B cells curtailed viremia and substantially affected pathogenesis in susceptible chickens. Together the data described here demonstrate the role of pulmonary B cells as the primary and predominant target cells and their importance for MDV pathogenesis. © 2009, Mary Ann Liebert, Inc..

Keywords:alpha interferon, beta interferon, gamma interferon, interleukin 18, interleukin 4, interleukin 6, transforming growth factor beta, animal cell, animal experiment, animal model, animal tissue, article, B lymphocyte, CD4+ T lymphocyte, CD8+ T lymphocyte, chicken, controlled study, dander, disease predisposition, herpes virus infection, interferon production, lung alveolus cell, lymphocyte depletion, macrophage, Mardivirus, nonhuman, pathogenesis, respiratory tract infection, spleen, target cell, viremia, virus replication, virus resistance, Animals, B-Lymphocytes, Bursa of Fabricius, Chickens, Cytokines, DNA, Viral, Dose-Response Relationship, Immunologic, Feathers, Female, Genetic Predisposition to Disease, Herpesvirus 2, Gallid, Insufflation, Lung, Lymphocyte Subsets, Marek Disease, Skin, T-Lymphocytes, Time Factors, Trachea, Viral Load, Virus Replication, Gallid herpesvirus 2, Gallus gallus, Herpesviridae
Subjects:C Biological Sciences > C500 Microbiology
Divisions:College of Science > School of Life Sciences
Related URLs:
ID Code:19859
Deposited On:30 Dec 2015 13:53

Repository Staff Only: item control page