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P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation

Shehzad, Aamir, Panneerselvam, Saravanan, Linow, Marina et al, Bocola, Marco, Roccatano, Danilo, Mueller-Dieckmann, Jochen, Wilmanns, Matthias and Schwaneberg, Ulrich (2013) P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation. Chemical Communications, 49 (41). p. 4694. ISSN 1359-7345

Full content URL: http://dx.doi.org/10.1039/c3cc39076d

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P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation
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Item Type:	Article
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Abstract

Solved crystal structures of P450 BM3 variants in complex with styrene provide on the molecular level a first explanation of how a positively charged surface residue inverts the enantiopreference of styrene epoxidation. The obtained insights into productive and non-productive styrene binding modes deepened our understanding of enantioselective epoxidation with P450 BM3.

Keywords:	P450 BM3 crystal structures, charged surface residue, Lys/Arg184, Inversion, Enantioselective styrene epoxidation
Subjects:	F Physical Sciences > F100 Chemistry
Divisions:	College of Science > School of Mathematics and Physics
ID Code:	19386
Deposited On:	27 Oct 2015 16:02

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