Micellar drug nanocarriers and biomembranes: how do they interact?

De Nicola, Antonio, Hezaveh, Samira, Zhao, Ying , Kawakatsu, Toshihiro, Roccatano, Danilo and Milano, Giuseppe (2014) Micellar drug nanocarriers and biomembranes: how do they interact? Physical Chemistry Chemical Physics, 16 (11). pp. 5093-5105. ISSN 1463-9076

Micellar drug nanocarriers and biomembranes: how do they interact?

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Pluronic based formulations are among the most successful nanomedicines and block-copolymer micelles including drugs that are undergoing phase I/II studies as anticancer agents. Using coarse-grained models, molecular dynamics simulations of large-scale systems, modeling Pluronic micelles interacting with DPPC lipid bilayers, on the μs timescale have been performed. Simulations show, in agreement with experiments, the release of Pluronic chains from the micelle to the bilayer. This release changes the size of the micelle. Moreover, the presence of drug molecules inside the core of the micelle has a strong influence on this process. The picture emerging from the simulations is that the micelle stability is a result of an interplay of drug–micelle core and block-copolymer–bilayer interactions. The equilibrium size of the drug vector shows a strong dependency on the hydrophobicity of the drug molecules embedded in the core of the micelle. In particular, the radius of the micelle shows an abrupt increase in a very narrow range of drug molecule hydrophobicity.

Keywords:Micellar, Nanocarrier, biomembranes, Pluronic micelles, Anticancer agents, Drug molecules, NotOAChecked
Subjects:F Physical Sciences > F170 Physical Chemistry
F Physical Sciences > F320 Chemical Physics
Divisions:College of Science > School of Mathematics and Physics
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ID Code:19330
Deposited On:27 Oct 2015 12:52

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