Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients

Damanhouri, L. H., Dromey, J. A., Christie, Michael R. , Nasrat, H. A., Ardawi, M. S. M., Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071

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Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients

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Aims: To determine the prevalence of autoantibodies in sera of Saudi diabetic patients including Type 1 and Type 2 diabetes mellitus (DM) and gestational diabetes mellitus (GDM) living in Jeddah, Saudi Arabia. Apart from data on the prevalence of islet-cell antibodies in patients in Ryhadh (Al-Attas et al. Freqency of islet cell antibodies in adult newly diagnosed diabetic patients. Ann Saudi Med 1990; 10: 369-373) immunological markers of autoimmune diabetes have not been explored in Saudi Arabians. Methods: Autoantibodies to GAD65 (GADA) and IA-2 (IA-2A) were determined using radio-immunoprecipitation assays. Results: In Type 1 DM patients, 54 were GADA+ and 27 were IA-2A+. A greater negative effect of disease duration was noted for IA-2A than for GADA positivity. Autoantibodies were more prevalent with younger age of onset. GADA were slightly more common in female Type 1 DM patients. In Type 2 DM, 8/99 patients were GADA+, and three of these patients with shorter disease duration were also IA-2A+. GADA, and particularly IA-2A, were associated with a younger age of onset of Type 2 DM and all the autoantibody-positive Type 2 DM patients were insulin-treated. GADA were detected in 2.2 of GDM patients, but none of these patients possessed IA-2A. Conclusions: The prevalence and associations of autoantibodies in Saudi diabetic patients are very similar to those reported for diabetic patients in other ethnic groups. © 2005 Diabetes UK.

Keywords:autoantibody, glutamate decarboxylase 65 antibody, ia 2 antibody, Ia antibody, insulin, oral antidiabetic agent, unclassified drug, adult, aged, antibody detection, antibody titer, article, autoimmune disease, disease duration, disease marker, ethnic group, female, human, insulin dependent diabetes mellitus, insulin treatment, major clinical study, male, non insulin dependent diabetes mellitus, onset age, pancreas islet, pregnancy diabetes mellitus, prevalence, radioimmunoprecipitation, Saudi Arabia, Adult, Age of Onset, Arabs, Autoantibodies, Autoimmune Diseases, Biological Markers, Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetes, Gestational, Glutamate Decarboxylase, Humans, Isoenzymes, Middle Aged, Pregnancy, Radioimmunoprecipitation Assay, Saudi Arabia
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
Divisions:College of Science > School of Life Sciences
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ID Code:18128
Deposited On:05 Aug 2015 15:49

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