Kyne, Sara H., Percy, Jonathon M., Pullin, Robert D. C. , Redmond, Joanna M. and Wilson, Peter G. (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 14770520
Full content URL: http://dx.doi.org/10.1039/c1ob06372c
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Org. Biomol. Chem. 2011 Kyne-1.pdf - Whole Document Restricted to Repository staff only 556kB |
| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
Difluoroalkenylzinc reagents prepared from 1-(2'-methoxy- ethoxymethoxy)-2,2,2-trifluoroethane and 1-(N,N-diethylcarbamoyloxy)-2,2,2- trifluoroethane at ice bath temperatures underwent Negishi coupling with a range of aryl halides in a convenient one pot procedure. While significant differences between the enol acetal and carbamate reagents were revealed, the Negishi protocol compared very favourably with alternative coupling procedures in terms of overall yields from trifluoroethanol.
| Keywords: | Negishi coupling, Dehydrofluorination/zincation, Density functional theory, Aryl halide |
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| Subjects: | F Physical Sciences > F160 Organic Chemistry F Physical Sciences > F161 Organometallic Chemistry |
| Divisions: | College of Science > School of Chemistry |
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| ID Code: | 17615 |
| Deposited On: | 09 Jun 2015 09:20 |
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