A historical perspective on radioisotopic tracers in metabolism and biochemistry

Lappin, Graham (2015) A historical perspective on radioisotopic tracers in metabolism and biochemistry. Bioanalysis, 7 (5). pp. 531-540. ISSN 1757-6180

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Radioisotopes are used routinely in the modern laboratory to trace and quantify a myriad of biochemical processes. The technique has a captivating history peppered with groundbreaking science and with more than its share of Nobel Prizes. The discovery of radioactivity at the end of the 19th century paved the way to understanding atomic structure and quickly led to the use of radioisotopes to trace the fate of molecules as they flowed through complex organic life. The 1940s saw the first radiotracer studies using homemade instrumentation and analytical techniques such as paper chromatography. This article follows the history of radioisotopic tracers from meager beginnings, through to the most recent applications. The author hopes that those researchers involved in radioisotopic tracer studies today will pause to remember the origins of the technique and those who pioneered this fascinating science. © 2015 Future Science Ltd.

Keywords:2 amino 3,8 dimethylimidazo4,5 fquinoxaline, carbon 11, carbon 13, carbon 14, Grignard reagent, iodine 131, methadone, phosphorus 32, radioisotope, radium, RNA polymerase, sitosterol, strychnine, sulfur 35, tracer, tritium, accelerator mass spectrometry, biochemistry, DNA binding, DNA replication, drug metabolism, half life time, human, isotope labeling, mass spectrometry, metabolism, nonhuman, positron emission tomography, radiation exposure, radioactivity, Review, scintillation counting, turnover time, bmjgoldcheck, NotOAChecked
Subjects:V Historical and Philosophical studies > V380 History of Science
C Biological Sciences > C741 Medical Biochemistry
Divisions:College of Science > School of Pharmacy
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ID Code:17372
Deposited On:06 May 2015 15:08

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