Exploring the glycolipidome via chemical mimicry

Lear, Martin (2010) Exploring the glycolipidome via chemical mimicry. In: EMBO Conference Series: Chemical Biology 2010, 22 - 25 Sep 2010, EMBL Heidelberg, Germany.

EMBL Abstract - MJ LEAR.pdf
EMBL Abstract - MJ LEAR.pdf - Abstract

Item Type:Conference or Workshop contribution (Keynote)
Item Status:Live Archive


Based on the traditions and skills of total synthesis, the chemical mimicry and targeting of the primary components of cells is gaining significant success in our understanding of diseases. Today, for example, the synthesis of exactly connected and stereochemically defined lipidated and glycan conjugates can be achieved to provide pure homogeneic materials for biological study. This is particularly important since closely related bioconjugated structures exist within cells and, within that dynamic cellular milieu, the unambiguous assignment of a molecular entity to a particular function (either singly or as a multivalent assembly) is an important goal to achieve. In our modest contributions to the field, we are exploring glycolipid tools to analyze infection, generate antibodies, and identify enzymes. In this talk, we shall highlight two projects: (1) the development of more specific variants of Orlistat (tetrahydrolipstatin, THL) to target the lipogenic activity of fatty acid synthase (FAS) and (2) the metabolic incorporation of an azido-myo-inositol into the phosphatidylinositols (PIs) of Baker’s yeast (S. cerevisiae).

Keywords:Biomimetic Synthesis, Biomimicry, Natural products, Bio-targeting, Biomolecular identification
Subjects:F Physical Sciences > F165 Biomolecular Chemistry
F Physical Sciences > F160 Organic Chemistry
F Physical Sciences > F163 Bio-organic Chemistry
Divisions:College of Science > School of Chemistry
Related URLs:
ID Code:17213
Deposited On:23 Apr 2015 08:55

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