Total synthesis and drug pursuits: the good, the bad, and the ugly

Lear, Martin (2012) Total synthesis and drug pursuits: the good, the bad, and the ugly. In: UK and European Lecture Tour, May - July 2012, St Andrews, Edinburgh, and Glasgow Universities (UK), EPFL (Lausanne, Switzerland), University of Strasbourg (France).

title_abstract_Martin_Lear.pdf - Abstract
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Item Type:Conference or Workshop contribution (Lecture)
Item Status:Live Archive


Synthetically speaking, the complex multifunctionalized environments of natural products typically limit the effectiveness of a chosen method to achieve a desired reaction. Carbanions, organometalics and counteractions, for example, will often experience competing interactions outside their designed or known roles. In a total synthesis or a chemical biology setting, each chosen method may be scrutinized on the basis of several interrelated criteria. Such ideals need to be sensibly balanced within a multistep synthesis; whether a key building block is being constructed or a key coupling step is being optimized (or even devised). Herein, we present key methods and strategies that were advanced en route to uncovering the chemistry and biology of the (1) laetirobins, (2) lipstatins, (3) platensimycins, and (4) bielschowskysin.

Keywords:Total synthesis, Natural products
Subjects:F Physical Sciences > F160 Organic Chemistry
Divisions:College of Science > School of Chemistry
ID Code:17203
Deposited On:23 Apr 2015 09:00

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