Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes

Lear, Martin (2013) Synthetic ventures into the platensimycins, bielschowskysins, lipstatins, and enediynes. In: Lecture Tour, July 2013, RIKEN, Waseda University, Keio University, Sophia University, Japan.

Talk_abstract_Martin_Lear.pdf - Abstract
Available under License Creative Commons Attribution.

Item Type:Conference or Workshop contribution (Keynote)
Item Status:Live Archive


Natural products often unite structure and function in unforeseen ways. Such facets have long driven total synthesis and drug discovery campaigns. The challenge for the chemist is to orchestrate a sequence of synthetic methods into a workable, clever strategy. For the biologist, it is to reveal and cleverly harness drug targets in new, therapeutic ways. In our research, we aim to tackle such challenges by advancing methods and strategies in organic and medicinal chemistry. Herein, we present key methods, strategies and bio-tactics that were advanced en route to uncovering the chemistry and biology of the (1) laetirobins, (2) lipstatins, (3) platensimycins, (4) antimalarial peptides and quinolines, (5) pathogenic glycolipids and inositol surrogates, and (6) bielschowskysin.

Keywords:Total synthesis, Natural products, Mode-of-action
Subjects:F Physical Sciences > F165 Biomolecular Chemistry
F Physical Sciences > F160 Organic Chemistry
F Physical Sciences > F163 Bio-organic Chemistry
Divisions:College of Science > School of Chemistry
ID Code:17202
Deposited On:23 Apr 2015 09:04

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