New directions for old drugs

Lear, Martin and Yao, Shao Q. (2010) New directions for old drugs. Project Report. National University of Singapore, Singapore.

FACULTY OF SCIENCE ANNUAL REPORT AY 2009-2010 [Asst_Prof_Martin_Lear_(CHEM) Highlight].pdf
FACULTY OF SCIENCE ANNUAL REPORT AY 2009-2010 [Asst_Prof_Martin_Lear_(CHEM) Highlight].pdf - Abstract

Item Type:Paper or Report (Project Report)
Item Status:Live Archive


With the beneficial goal of generating new applications from known drugs, the chemistry and biology groups of Dr. Martin J. Lear and Prof. Yao Shao Qin have teamed up to develop an anti-cancer agent out of the FDA-approved anti-obesity drug called Orlistat (also known as tetrahydrolipstatin, THL). Their strategy combines the techniques of total synthesis and chemical proteomics to generate THL-probes capable of trapping off-target proteins.

Keywords:Total synthesis, Chemical proteomics
Subjects:F Physical Sciences > F165 Biomolecular Chemistry
F Physical Sciences > F160 Organic Chemistry
F Physical Sciences > F163 Bio-organic Chemistry
Divisions:College of Science > School of Chemistry
ID Code:17188
Deposited On:23 Apr 2015 14:11

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