Synthesis and use of fluorophore-tagged antimalarials

National University of Singapore (2012) Synthesis and use of fluorophore-tagged antimalarials. US20120100555 A1.

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Item Type:Patent
Item Status:Live Archive


This invention includes a fluorophore-tagged antimalarial represented by the following structural formula (1) or a salt thereof. This invention relates to the synthesis of fluorophore-tagged antimalarials and describes the synthesis of a fluorophore-tagged antimalarial. These fluorophore-tagged antimalarials can be used to image live cells to determine the location of the antimalarial in the cell, identify drug resistance and growth related pathways in Plasmodium isolates, identify new drug targets and chemo-sensitizers to reverse drug resistance.

Additional Information:Also published as EP2448574A1, EP2448574A4, WO2011002415A1.
Keywords:Drug labelling, Drug resistance, Fluorescent labels, Plasmodium, Malaria detection
Subjects:F Physical Sciences > F165 Biomolecular Chemistry
F Physical Sciences > F160 Organic Chemistry
C Biological Sciences > C500 Microbiology
Divisions:College of Science > School of Chemistry
ID Code:17181
Deposited On:23 Apr 2015 14:09

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