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Convenient route to derivatives of the 2-deoxysugar subunits of the kedarcidin chromophore: L-mycarose and L-kedarosamine

Lear, Martin J. and Hirama, Masahiro (1999) Convenient route to derivatives of the 2-deoxysugar subunits of the kedarcidin chromophore: L-mycarose and L-kedarosamine. Tetrahedron Letters, 40 (26). pp. 4897-4900. ISSN 0040-4039

Full content URL: http://dx.doi.org/10.1016/S0040-4039(99)00906-5

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Convenient-route-to-derivatives-of-the-2-deoxysugar-subunits-of-the-Kedarcidin-chromophore-L-mycarose-and-L-kedarosamine_1999_Tetrahedron-Letters.pdf
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Item Type:	Article
Item Status:	Live Archive

Abstract

An efficient and practical synthesis of mycarose and kedarosamine derivatives has been devised from ethyl (S)-lactate v/a a versatile (E)-alkene intermediate. Noteworthy transformations include a highly trans-selective one-pot Julia olefination protocol and intramolecular cyclisation of a 2,3-epoxy carbamate.

Keywords:	Natural enediynes, Total synthesis studies, 2-Deoxy sugars
Subjects:	F Physical Sciences > F160 Organic Chemistry
Divisions:	College of Science > School of Chemistry
ID Code:	17128
Deposited On:	16 Apr 2015 13:13

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