Click-based synthesis and proteomic profiling of lipstatin analogues

Ngai, Mun H., Yang, Peng-Yu, Liu, Kai , Shen, Yuan, Wenk, Markus R., Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345

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Chem.Commun-2010-8335 (with November front-cover).pdf
Chem.Commun-2010-8335 (with November front-cover).pdf

Item Type:Article
Item Status:Live Archive


Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.

Keywords:Total synthesis, Natural product, Orlistat, Chemical proteomics, Fatty acid synthase
Subjects:F Physical Sciences > F165 Biomolecular Chemistry
F Physical Sciences > F160 Organic Chemistry
F Physical Sciences > F163 Bio-organic Chemistry
Divisions:College of Science > School of Chemistry
ID Code:17111
Deposited On:16 Apr 2015 15:09

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