Ngai, Mun H., Yang, Peng-Yu, Liu, Kai , Shen, Yuan, Wenk, Markus R., Yao, Shao Q. and Lear, Martin J. (2010) Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications, 46 (44). p. 8335. ISSN 1359-7345
Full content URL: http://dx.doi.org/10.1039/c0cc01276a
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Chem.Commun-2010-8335 (with November front-cover).pdf 2MB |
| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.
| Keywords: | Total synthesis, Natural product, Orlistat, Chemical proteomics, Fatty acid synthase |
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| Subjects: | F Physical Sciences > F165 Biomolecular Chemistry F Physical Sciences > F160 Organic Chemistry F Physical Sciences > F163 Bio-organic Chemistry |
| Divisions: | College of Science > School of Chemistry |
| ID Code: | 17111 |
| Deposited On: | 16 Apr 2015 15:09 |
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