Ghosh, Shibaji K., Butler, Mark S. and Lear, Martin J. (2012) Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters, 53 (22). pp. 2706-2708. ISSN 0040-4039
Full content URL: http://dx.doi.org/10.1016/j.tetlet.2012.03.071
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
The mevalonate-independent pathway (MIP) is an interesting avenue for antimicrobial lead discovery. Here, we present a unified enantioselective synthesis of all four stereoisomers of 2-C-methyltetrol. These are useful building blocks of many bioactive natural products, including 2-C-methylerythritol phosphate (MEP) of the MIP biosynthetic pathway.
| Keywords: | Mevalonate, Enantiodivergent, Malaria, Tetraols |
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| Subjects: | F Physical Sciences > F165 Biomolecular Chemistry F Physical Sciences > F160 Organic Chemistry F Physical Sciences > F163 Bio-organic Chemistry |
| Divisions: | College of Science > School of Chemistry |
| ID Code: | 17104 |
| Deposited On: | 16 Apr 2015 13:00 |
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