Uncertainties of size measurements in electron microscopy characterization of nanomaterials in foods

Dudkiewicz, A., Boxall, A. B. A., Chaudhry, Q. , Molhave, K., Tiede, K., Hofmann, P. and Linsinger, T. P. J. (2015) Uncertainties of size measurements in electron microscopy characterization of nanomaterials in foods. Food Chemistry, 176 . pp. 472-479. ISSN 0308-8146

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Electron microscopy is a recognized standard tool for nanomaterial characterization, and recommended by the European Food Safety Authority for the size measurement of nanomaterials in food. Despite this, little data have been published assessing the reliability of the method, especially for size measurement of nanomaterials characterized by a broad size distribution and/or added to food matrices. This study is a thorough investigation of the measurement uncertainty when applying electron microscopy for size measurement of engineered nanomaterials in foods. Our results show that the number of measured particles was only a minor source of measurement uncertainty for nanomaterials in food, compared to the combined influence of sampling, sample preparation prior to imaging and the image analysis. The main conclusion is that to improve the measurement reliability, care should be taken to consider replications and matrix removal prior to sample preparation.

Additional Information:Part of work leading to this publication was performed at the University of York and Food and Environment Research Agency.
Keywords:Nanomaterials; Electron microscopy; Food; Measurement uncertainty; Minimal sample intake, Awaiting, bmjgoldcheck, NotOAChecked
Subjects:D Veterinary Sciences, Agriculture and related subjects > D610 Food Science
F Physical Sciences > F110 Applied Chemistry
F Physical Sciences > F180 Analytical Chemistry
Divisions:College of Science > National Centre for Food Manufacturing
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ID Code:16390
Deposited On:13 Jan 2015 13:48

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