Fallows, Andrew J., Singh, Ishwar, Dondi, Ruggero , Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060
Documents |
|
![]() |
PDF
__ddat02_staffhome_jpartridge_ol502203y.pdf - Whole Document Restricted to Repository staff only 824kB |
Item Type: | Article |
---|---|
Item Status: | Live Archive |
Abstract
Two advances in the synthesis of hairpin pyrrole-imidazole polyamides (PAs) are described. First, the application of a convergent synthetic strategy is shown, involving the Boc-based solid phase synthesis of a C-terminal fragment and the solution phase synthesis of the N-terminal fragment. Second a new hybrid resin is developed that allows for the preparation of hairpin PAs lacking a C-terminal beta-alanine tail. Both methods are compatible with a range of coupling reagents and provide a facile, modular route to prepare PA libraries in high yield and crude purity.
Keywords: | DNA-binding polyamides, Hairpin pyrrole-imidazole polyamides, Convergent synthetic strategy, C-terminal fragment, N-terminal fragment, Coupling reagents, NotOAChecked |
---|---|
Subjects: | F Physical Sciences > F160 Organic Chemistry F Physical Sciences > F100 Chemistry |
Divisions: | College of Science > School of Pharmacy |
Related URLs: | |
ID Code: | 16297 |
Deposited On: | 17 Dec 2014 16:10 |
Repository Staff Only: item control page