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Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

Cousins, Alex R. O., Ritson, Dougal, Sharma, Pallavi , Stevens, Malcolm F. G., Moses, John E. and Searle, Mark S. (2014) Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications, 50 . pp. 15202-15205. ISSN 1359-7345

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Abstract

Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based ‘click’ ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.

Keywords:G-quadruplex, DNA sequence, 'click' ligand, Oxazoles, NotOAChecked
Subjects:F Physical Sciences > F160 Organic Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:15968
Deposited On:11 Nov 2014 14:11

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