Salivary cortisol response to awakening in chronic fatigue syndrome

Roberts, Amanda D. L., Wessley, Simon, Chalder, Trudie , Papadopoulos, Andrew and Cleare, Anthony. J. (2004) Salivary cortisol response to awakening in chronic fatigue syndrome. The British Journal of Psychiatry, 184 (2). pp. 136-141. ISSN 0007-1250

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Background: There is accumulating evidence of hypothalamic-pituitary-adrenal (HPA) axis disturbances in chronic fatigue syndrome (CFS). The salivary cortisol response to awakening hasbeen described recentlyas a non-invasive test of the capacityof the HP Aaxis to respond to stress. The results of this test correlate closely with those of more invasive
dynamic tests reported in the literature; furthermore, i tcan be undertaken in a naturalistic setting.
Aims: To assess the HPA axis using the salivary cortisol response to awakening in CFS.
Method: We measured salivary cortisol upon awakening and 10, 20, 30 and 60 min afterwards in 56 patients with CFS and 35 healthy volunteers.
Results: Patients had a lower cortisol response to awakening, measured by the area under the curve.
Conclusions: This naturalistic test of the HPA axis response to stress showed impaired HPA axis function in CFS.

Keywords:Chronic fatigue syndrome, HPA Axis, Salivary cortisol response
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
C Biological Sciences > C841 Health Psychology
Divisions:College of Social Science > School of Psychology
ID Code:15814
Deposited On:26 Oct 2014 20:57

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