Ultrasound assessment of skin and wound tissue: comparison with histology

Rippon, M. G., Springett, K., Walmsley, R. , Patrick, K. and Millson, S. (1998) Ultrasound assessment of skin and wound tissue: comparison with histology. Skin Research and Technology, 4 (3). pp. 147-154. ISSN 0909-752X

Full content URL: http://dx.doi.org/10.1111/j.1600-0846.1998.tb00101...

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Item Type:Article
Item Status:Live Archive


Background/aims: Ultrasound is a valuable technique in dermatological assessment as it is non-invasive. This is particularly attractive for monitoring and evaluating wound healing. However, there is a limited literature on the use of ultrasound in monitoring wound healing.

Methods: In this study, the structures of skin (human and porcine) and healing wounds (porcine) were visualised using ultrasound (20 MHz) and compared with histology from the same site. Measurements of various features were undertaken using both ultrasound and histometric techniques and the results from each compared. Hydroxyproline levels were also measured and correlated with ultrasound measurement of granulation tissue.

Results: The echogenic characteristics of tissues are described. There was excellent correlation (r=0.96, P > 0.0001) between the ultrasound measurements and histology for porcine and human cadaver measurements. Ultrasound and histology measurements of acute porcine wounds also correlated well (r=0.96,P<0.0001). Comparison of hydroxyproline analysis with ultrasound measurements of fibrous granulation tissue (r=0.82,P > 0.001) indicates that ultrasound may be used to visualise accumulation of this tissue in wounds.

Conclusions: Ultrasonography has been shown to be a useful, reliable, quantifiable technique for the assessment of wound healing.

Additional Information:Article first published online: 27 OCT 2006
Keywords:Ultrasound imaging, Skin measurements, Wound healing, Collagen accumulation
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry
C Biological Sciences > C500 Microbiology
Divisions:College of Science > School of Life Sciences
ID Code:15334
Deposited On:13 Oct 2014 12:30

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