Proton computed tomography reconstruction using a backprojection-then-filtering approach

Poludniowski, G., Allinson, N. M. and Evans, P. M. (2014) Proton computed tomography reconstruction using a backprojection-then-filtering approach. Physics in Medicine and Biology, 59 (11). p. 2569. ISSN 0031-9155

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A novel approach to proton CT reconstruction using backprojection-then- filtering is proposed. A list-mode algorithm is formulated accommodating non-linear proton paths. The analytical form is derived for the deblurring kernel necessary for the filtering step. Further, a finite matrix correction is derived to correct for the limited size of the backprojection matrix. High quantitative accuracy in relative stopping power is demonstrated (≤ 0.1%) using Monte Carlo simulations. This accuracy makes the algorithm a promising candidate for future proton CT systems in proton therapy applications. For the purposes of reconstruction, each proton path in the object-of- interest was estimated based on a cubic spline fit to the proton entry and exit vectors. The superior spatial-resolution of the backprojection-then-filtering (BPF) method over the standard filtering-then-backprojection (FBP) approach is demonstrated. As the BPF algorithm requires only one backprojection and filtering operation on a scan data set, it also offers computational advantages over an iterative reconstruction approach.

Keywords:Computed Tomography, Proton therapy, backprojection, NotOAChecked
Subjects:F Physical Sciences > F350 Medical Physics
Divisions:College of Science > School of Computer Science
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ID Code:14745
Deposited On:21 Aug 2014 13:28

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