C-Peptide as a therapeutic tool in diabetic nephropathy

Hills, C. E., Brunskill, N. J. and Squires, P. E. (2010) C-Peptide as a therapeutic tool in diabetic nephropathy. American Journal of Nephrology, 31 (5). pp. 389-397. ISSN 0250-8095

Full content URL: http://dx.doi.org/10.1159/000289864

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Background/Aims: Insulin is synthesised as a pro-hormone with an interconnecting C-peptide, cleaved during post-translational modification. This review discusses growing evidence which indicates that C-peptide is biologically active, benefiting microvascular complications associated with diabetes. Methods: To explore the renoprotective role of C-peptide in diabetic nephropathy (DN), we reviewed the literature using PubMed for English language articles that contained key words related to C-peptide, kidney and DN. Results: Numerous studies have demonstrated that C-peptide ameliorates a number of the structural and functional renal disturbances associated with uncontrolled hyperglycaemia in human and animal models of type 1 diabetes mellitus that lead to the development and progression of nephropathy, including abrogation of glomerular hyperfiltration, reduced microalbuminuria, decreased mesangial expansion and increased endothelial nitric oxide synthase levels. The in vitro exposure of kidney proximal tubular cells to physiological concentrations of C-peptide activates extracellular signal-regulated kinase, phosphatidylinositol 3-kinase, protein kinase C, elevates intracellular calcium, and stimulates tran scription factors NF-kappa B and peroxisome proliferator-activated receptor-gamma. Conclusion: Burgeoning studies suggest that C-peptide is more than merely a link between the A and B chains of the proinsulin molecule and represents a future therapeutic tool in reducing complications of DN. Copyright (C) 2010 S. Karger AG, Basel

Subjects:Library of Congress Subject Areas > R Medicine > RC Internal medicine
Divisions:College of Science > School of Life Sciences
ID Code:14068
Deposited On:20 Apr 2011 10:58

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