Chemoselective palladium-catalyzed cyanation of alkenyl halides

Powell, Kimberley J., Han, Li-Chen, Sharma, Pallavi and Moses, John E. (2014) Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters, 16 (8). pp. 2158-2161. ISSN 1523-7060

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Abstract

A palladium-catalyzed cyanation of alkenyl halides using acetone cyanohydrin is described. A number of structurally diverse alkenylic nitrile containing compounds was prepared in one step under optimized conditions. The reaction proved to be efficient, chemoselective, easy to perform, and tolerant of a number of functional groups.

Keywords:Cyanation, Alkenyl nitrile, Palladium catalysis, Acetone cyano hydrin, oapaid, NotOAChecked
Subjects:F Physical Sciences > F160 Organic Chemistry
Divisions:College of Science > School of Life Sciences
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ID Code:13766
Deposited On:09 Apr 2014 08:50

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