Vibrational spectroscopic study of terbutaline hemisulphate

Ali, H. R. H., Edwards, H. G. M., Kendrick, J. and Scowen, I. J. (2009) Vibrational spectroscopic study of terbutaline hemisulphate. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 72 (4). pp. 715-719. ISSN 13861425

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The Raman spectrum of terbutaline hemisulphate is reported for the first time, and molecular assignments are proposed on the basis of ab initio BLYP DFT calculations with a 6-31G* basis set and vibrational frequencies predicted within the quasi-harmonic approximation; these predictions compare favourably with the observed vibrational spectra. Comparison with previously published infrared data explains several spectral features. The results from this study provide data that can be used for the preparative process monitoring of terbutaline hemisulphate, an important β 2 agonist drug in various dosage forms and its interaction with excipients and other components. © 2008 Elsevier B.V. All rights reserved.

Keywords:Drug dosage, Drug interactions, Molecular spectroscopy, Process engineering, Process monitoring, Raman scattering, Raman spectroscopy, Spectroscopic analysis, Spectrum analysis, Sulfur compounds, Ab initio structural calculations, Basis sets, DFT calculations, Dosage forms, Harmonic approximations, Infrared datum, Raman spectrum, Spectral features, Spectroscopic studies, Terbutaline hemisulphate, Vibrational frequencies, Infrared spectroscopy, beta adrenergic receptor stimulating agent, terbutaline, animal, article, chemical structure, chemistry, Raman spectrometry, vibration, Adrenergic beta-Agonists, Animals, Molecular Structure, Spectrum Analysis, Raman, Terbutaline, Vibration
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:13041
Deposited On:19 Mar 2014 18:00

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