In situ monitoring of pH titration by Raman spectroscopy

Elbagerma, M. A., Azimi, G., Edwards, H. G. M. , Alajtal, A. I. and Scowen, I. J. (2010) In situ monitoring of pH titration by Raman spectroscopy. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 75 (5). pp. 1403-1410. ISSN 1386-1425

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Molecular speciation of organic compounds in solution is essential for the understanding of ionic complexation. The Raman technique was chosen because it allows the identification of compounds in different states, and it can give information about the molecular geometry from the analysis of the vibrational spectra. The effect of pH on organic compounds can give information about the ionisation of molecule species. In this study the ionisation steps of salicylic acid and paracetamol have been studied by means of potentiometry coupled with Raman spectroscopy at 30.0 °C in a solution of ionic strength 0.96 mol dm -3 (KNO 3) and 0.04 mol dm -3 (HNO 3). The protonation and deprotonation behaviour of the molecules were studied in different pH regions. The abundance of the three different species in the Raman spectra of aqueous salicylic acid have been identified satisfactorily, characterised, and determined by numeric treatment of the data using a multiwavelength curve-fitting program and confirmed with the observed spectral information. © 2010 Elsevier B.V. All rights reserved.

Keywords:Acidity constants, In-situ monitoring, Multi-wavelength spectroscopy, Non-linear least squares, Paracetamol, Salicylic acids, Acidity, Complexation, Curve fitting, Ionic strength, Ionization, Organic compounds, Raman scattering, Raman spectroscopy, pH effects, paracetamol, salicylic acid, article, chemistry, kinetics, methodology, pH, potentiometry, Raman spectrometry, solution and solubility, statistical parameters, titrimetry, Acetaminophen, Hydrogen-Ion Concentration, Limit of Detection, Salicylic Acid, Solutions, Spectrum Analysis, Raman, Titrimetry
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:13032
Deposited On:19 Mar 2014 18:50

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