Haemoglobin polymorphism in the Bank vole, Clethrionomys glareolus, in Britain

Hall, S. J. G. (1979) Haemoglobin polymorphism in the Bank vole, Clethrionomys glareolus, in Britain. Journal of Zoology, 187 (2). pp. 153-160. ISSN 0952-8369

Full content URL: http://dx.doi.org/10.1111/j.1469-7998.1979.tb03939...

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Three hundred and twenty-two Clethrionomys glareolus from 17 localities in England, Wales and southern Scotland were typed for haemoglobin and two phenotypes were discovered. They have been designated HbS and HbF. The latter is more electronegative at physiological pH. The nature of the molecular difference between the phenotypes was examined and it was concluded that HbF polymerises more readily than does HbS. Haematological investigations showed that although the red cells of animals with HbF contain more potassium, thereby ensuring electrostatic neutrality, there has not been concomitant dilution of the cell contents. It is suggested that the osmotic stress imposed by this high concentration of particles might be reduced by in vivo polymerisation of haemoglobin. HbS was found to predominate in the north of Britain and HbF in the south. As none of the populations sampled contained animals of both types, it is not yet known whether there is a north-south cline in haemoglobin type, or a sharp disjunction.

Additional Information:Article first published online: 20 AUG 2009
Subjects:D Veterinary Sciences, Agriculture and related subjects > D300 Animal Science
Divisions:College of Science > School of Life Sciences
ID Code:12864
Deposited On:13 Jan 2014 10:48

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